
The Power of Polynucleotides: How They're Best Administered for Skin Rejuvenation
Mar 3
4 min read
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In the ever-evolving world of skincare, new treatments and ingredients continually emerge, offering promising results for those seeking youthful, radiant skin. One of the latest trends in the beauty industry is polynucleotides, a groundbreaking ingredient with powerful regenerative properties. If you're unfamiliar with polynucleotides and how they can benefit your skin, keep reading to learn more about these nucleic acid-based compounds, their benefits, and the best ways to administer them for optimal results.

What Are Polynucleotides?
Polynucleotides (PN) are naturally occurring nucleic acid fragments made up of DNA or RNA molecules. In the context of skincare, these compounds are typically derived from salmon DNA, which is rich in beneficial molecules that promote skin health and repair. Polynucleotides are known for their ability to stimulate the skin's regeneration processes, making them ideal for promoting collagen production, hydration, and skin healing.
When applied to the skin, polynucleotides work at a cellular level, enhancing the skin's natural repair mechanisms, reducing inflammation, and boosting collagen synthesis. As a result, polynucleotides are highly effective for treating a variety of skin concerns, from fine lines and wrinkles to dry skin, pigmentation, and acne scars.
Benefits of Polynucleotides for the Skin
Polynucleotides offer a multitude of skin benefits that make them an excellent addition to any skincare regimen or aesthetic treatment. Some of the key advantages include:
Collagen Production: Polynucleotides stimulate the production of collagen, a vital protein that keeps the skin firm, plump, and youthful. As we age, collagen production decreases, leading to sagging and wrinkles. Polynucleotides help reverse this process by encouraging collagen synthesis.
Enhanced Skin Hydration: Polynucleotides have powerful moisture-retaining properties, helping to hydrate and plump the skin. This makes them particularly beneficial for individuals with dry, dehydrated, or sensitive skin.
Skin Regeneration: The healing properties of polynucleotides promote faster skin regeneration and repair. This makes them a great option for those with scars, pigmentation, or other forms of skin damage.
Anti-Inflammatory Effects: Polynucleotides can reduce inflammation in the skin, helping to calm irritation and redness. This makes them an excellent choice for individuals with conditions like rosacea or acne.
Improved Skin Elasticity and Tone: By promoting collagen and elastin production, polynucleotides contribute to better skin elasticity and overall skin tone, leaving you with firmer, more youthful-looking skin.
How Are Polynucleotides Best Administered?
Polynucleotides can be administered in several different ways, depending on the desired results, the area being treated, and the condition of the skin. Let’s explore the most common methods of administering polynucleotides:
1. Microneedling with Polynucleotides
Microneedling is a non-invasive treatment that involves the use of fine needles to create tiny punctures in the skin. This stimulates the body’s natural healing response and encourages collagen production. When combined with polynucleotides, the treatment becomes even more effective.
How it works:The microneedles create microchannels in the skin, allowing the polynucleotides to penetrate deeper into the dermis, where they can work more effectively. This combination enhances collagen synthesis and skin regeneration, leading to smoother, more hydrated, and youthful skin over time.
Benefits:
Stimulates collagen production.
Improves skin texture, tone, and elasticity.
Boosts hydration and repair.
Ideal for treating surface-level concerns like fine lines, acne scars, and pigmentation.
Best for:Those looking for gradual, long-term improvements in skin texture and appearance. Microneedling with polynucleotides is ideal for treating superficial concerns like fine lines, acne scars, or general skin rejuvenation.
2. Injection of Polynucleotides
Polynucleotide injections involve directly injecting the compound into the dermis, where it can be absorbed by the skin more quickly. This method delivers the polynucleotides to the deeper layers of the skin, providing a more direct and concentrated effect.
How it works:The polynucleotides are injected directly into the skin, where they can stimulate collagen and elastin production, hydrate, and regenerate the skin more effectively than topical treatments. The injection method provides faster results, making it a great choice for those with more advanced signs of aging or specific skin concerns.
Benefits:
Provides faster and more targeted results.
Ideal for treating deeper skin issues like sagging, deep wrinkles, or volume loss.
Promotes skin tightening, hydration, and elasticity.
Can address more localized concerns, such as under-eye hollows or nasolabial folds.
Best for:Those seeking quicker, more noticeable results, especially for specific areas such as the under-eye area, neck, or around the mouth. It’s also ideal for those looking to address deeper wrinkles or loss of skin elasticity.
3. Topical Application of Polynucleotides
While the injection and microneedling methods offer deeper penetration, polynucleotides can also be applied topically as part of a daily skincare regimen. Many skincare products, such as serums or masks, now include polynucleotides as an ingredient for at-home use.
How it works:Topical polynucleotides are absorbed into the skin’s surface layers, where they help hydrate, regenerate, and repair. While this method is less intensive than microneedling or injections, it can still offer noticeable improvements in skin hydration and texture with consistent use.
Benefits:
Convenient and non-invasive.
Can be used as a daily skincare treatment.
Helps improve skin texture, tone, and hydration over time.
Best for:Those looking for a non-invasive, at-home solution for skin hydration, texture improvement, and general skin rejuvenation.
Which Method is Right for You?
The best method for administering polynucleotides depends on your skin concerns, goals, and the results you’re looking to achieve. Here’s a quick breakdown:
Microneedling with Polynucleotides: Ideal for overall skin rejuvenation, improving texture, and treating superficial skin issues like fine lines and scars.
Injection of Polynucleotides: Best for more immediate, targeted results, especially for deeper wrinkles, volume loss, and sagging skin.
Topical Application: A convenient, non-invasive option for ongoing hydration and maintenance, ideal for those who want a more subtle improvement in skin texture.
Ultimately, consulting with a licensed skincare professional can help you determine which method is best for your unique needs and skin type. Whether you choose microneedling, injections, or topical application, polynucleotides are a powerful tool in the quest for healthier, more youthful skin.
Final Thoughts
Polynucleotides are a fantastic addition to the world of skincare, offering impressive benefits for anyone looking to rejuvenate their skin, reduce the appearance of wrinkles, and enhance hydration. With multiple methods of administration to choose from, you can tailor your treatment to your skin’s specific needs and goals. Whether you opt for microneedling, injections, or topical products, polynucleotides can help you achieve smoother, firmer, and more radiant skin.
Book a consultation & lets see how they can change your skin!